Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583679 | 0.90 | DRD2 (0.44) | MAPTNPSR1DRD3DRD2HTR1A | |
| SCHEMBL7582663 | 0.90 | CHRNA7 (0.41) | MAPTDRD3DRD2DRD4HTR1A | |
| SCHEMBL7582205 | 0.89 | DRD2 (0.38) | MAPTNPSR1DRD3DRD2HTR1A | |
| SCHEMBL7584122 | 0.86 | MAPT (0.38) | MAPTNPSR1DRD3DRD2HRH4 | |
| SCHEMBL7955784 | 0.86 | MAPT (0.38) | MAPTNPSR1DRD3DRD2HRH4 | |
| SCHEMBL7583655 | 0.86 | CHRNA7 (0.39) | DRD3DRD2DRD4BCL2BAK1 | |
| SCHEMBL7589752 | 0.85 | DRD2 (0.36) | MAPTNPSR1DRD3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL7585021 | 0.85 | DRD2 (0.35) | MAPTNPSR1DRD3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL7584884 | 0.85 | DRD2 (0.35) | MAPTNPSR1DRD3DRD2DRD4 | |
| SCHEMBL7583011 | 0.85 | HTR2C (0.38) | NPSR1DRD3DRD2DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |