Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.49 |
| ▸ | HTR1B | P28222 | 11/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893689 | 0.91 | HTR1D (0.62) | HTR1DHTR1BHTR1AKDM4EMEN1 | |
| SCHEMBL8632679 | 0.74 | HTR1D (0.57) | HTR1DHTR1BHTR1A | |
| SCHEMBL7371196 | 0.73 | HTR1D (0.83) | HTR1DHTR1B | |
| SCHEMBL7587753 | 0.73 | HTR1D (0.46) | HTR1DHTR1BHTR1A | |
| SCHEMBL9189284 | 0.72 | HTR1D (0.46) | HTR1DHTR1BHTR1ACYP1A2TSHR | |
| SCHEMBL8676889 | 0.72 | HTR1A (0.65) | HTR1DHTR1BHTR1AKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7936160 | 0.71 | HTR1A (0.64) | HTR1DHTR1BHTR1AKDM4EMEN1 | |
| SCHEMBL8672825 | 0.70 | HTR1A (0.59) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL8676875 | 0.70 | CHRM2 (0.64) | HTR1DHTR1BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL7936577 | 0.69 | CHRM2 (0.63) | HTR1DHTR1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997041101-A1 | ENANTIOMERS OF TRANS-BENZ[E]INDOLE COMPOUNDS, THEIR PREPARATION AND UTILITY AS DOPAMINE-D3 RECEPTOR SELECTIVE AGENTS | NOVO NORDISK A/S (DK) | 1997-11-06 | — | — | WO | disclosed |