Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.62 |
| ▸ | HTR1B | P28222 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7587763 | 0.91 | HTR1D (0.49) | HTR1DHTR1BKDM4EMEN1CYP1A2 | |
| SCHEMBL8315256 | 0.77 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL11275455 | 0.74 | HTR1D (0.61) | HTR1DHTR1BKDM4EMEN1CYP1A2 | |
| SCHEMBL2599107 | 0.74 | HTR1A (0.76) | HTR1DHTR1BMEN1CYP1A2TSHR | |
| SCHEMBL2599112 | 0.74 | HTR1A (0.76) | HTR1DHTR1BMEN1CYP1A2TSHR | |
| SCHEMBL8312983 | 0.74 | HTR1B (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL9669337 | 0.72 | HTR1D (0.60) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL9670474 | 0.71 | HTR1D (0.32) | HTR1DHTR1B | |
| SCHEMBL2599184 | 0.69 | DRD2 (0.79) | CYP1A2CYP3A4TSHRDRD2HTR1A | |
| SCHEMBL2599183 | 0.69 | DRD2 (0.79) | CYP1A2CYP3A4TSHRDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |