Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 12/20 | 0.69 |
| ▸ | ADRA2B known ✓ | P18089 | 12/20 | 0.69 |
| ▸ | ADRA2C known ✓ | P18825 | 12/20 | 0.69 |
| ▸ | F2 known ✓ | P00734 | 1/20 | 0.56 |
| ▸ | PTGIR | P43119 | 6/20 | 0.61 |
| ▸ | C1R | P00736 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | KLK1 | P06870 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8953899 | 0.93 | ADRA2A (0.79) | ADRA2AADRA2BADRA2CPTGIR | |
| Hydrochloric Acid SCHEMBL3899129 | 0.91 | ADRA2A (0.77) | ADRA2AADRA2BADRA2CPTGIR | |
| Hydrochloric Acid SCHEMBL7601691 | 0.91 | ADRA2A (0.77) | ADRA2AADRA2BADRA2CPTGIR | |
| SCHEMBL5806616 | 0.85 | ADRA2A (0.76) | ADRA2AADRA2BADRA2CPTGIR | |
| SCHEMBL7588328 | 0.83 | ADRA2A (0.64) | ADRA2AADRA2BADRA2CPTGIRF2 | |
| SCHEMBL27275424 | 0.80 | ADRA2A (0.77) | ADRA2AADRA2BADRA2CPTGIRF2 | |
| Hydrochloric Acid SCHEMBL7601687 | 0.78 | ADRA2A (0.75) | ADRA2AADRA2BADRA2CPTGIRPRSS1 | |
| SCHEMBL25605204 | 0.78 | ADRA2A (0.75) | ADRA2AADRA2BADRA2CPTGIRPRSS1 | |
| SCHEMBL7753126 | 0.76 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CPTGIR | |
| SCHEMBL6158137 | 0.76 | ADRA2A (0.66) | ADRA2AADRA2BADRA2CPTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4777182-A | ENZYME, HORMONE, COMPLEMENT INHIBITORS | TORII & CO., LTD. (JP) | 1988-10-11 | — | — | US | claimed |
| EP-0802179-B1 | SUBSTITUTED AMIDINONAPHTHYL ESTER DERIVATIVES | TORII PHARMACEUTICAL CO LTD (JP) | 2002-08-21 | — | — | EP | disclosed |
| US-5885990-A | FIBRINOLYSIS PROMOTING ACTION; THROMBOLYSIS ACTION | TORII PHARMACEUTICAL CO., LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0802179-A1 | SUBSTITUTED AMIDINONAPHTHYL ESTER DERIVATIVES | TORII PHARMACEUTICAL CO., LTD. (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0190356-B1 | NOVEL AMIDINE COMPOUNDS | TORII & CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4820730-A | ANTI-TRYPSIN, ANTI-PLASMIN, ANTI-THROMBIN, ANTI-KALLIKREIN ACTIVITY | TORII & CO., LTD. (JP) | 1989-04-11 | — | — | US | disclosed |
| US-4777182-A | ENZYME, HORMONE, COMPLEMENT INHIBITORS | TORII & CO., LTD. (JP) | 1988-10-11 | — | — | US | disclosed |
| EP-0190356-A1 | NOVEL AMIDINE COMPOUNDS | TORII & CO., LTD. (JP) | 1986-08-13 | — | — | EP | disclosed |