Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6274703 | 1.00 | MEN1 (0.31) | MEN1HSP90AA1KMT2AATMALDH1A1 | |
| Hydrochloric Acid SCHEMBL7563055 | 0.81 | GABRA1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL7563066 | 0.81 | GABRA1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL7592327 | 0.75 | ALDH1A1 (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6272010 | 0.75 | ALDH1A1 (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7588063 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL6271878 | 0.69 | — | — | |
| SCHEMBL27608664 | 0.63 | CYP2A6 (0.35) | ATMALDH1A1 | |
| Hydrochloric Acid SCHEMBL1450514 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL6274701 | 0.62 | MEN1 (0.31) | MEN1HSP90AA1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841375-B1 | Impact-resistant polystyrene resin composition | UBE INDUSTRIES (JP) | 2002-05-22 | — | — | EP | disclosed |
| US-5981667-A | CONTAINING DISPERSED PARTICLES OF HIGH-CIS HIGH-VINYL POLYBUTADIENE COMPRISING FROM 65 TO 95% CIS-1,4-STRUCTURES AND FROM 30 TO 4% 1,2-STRUCTURES | UBE INDUSTRIES, LTD. (JP) | 1999-11-09 | — | — | US | disclosed |
| EP-0841375-A1 | Impact-resistant polystyrene resin composition | UBE INDUSTRIES, LTD. (JP) | 1998-05-13 | — | — | EP | disclosed |