Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F known ✓ | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1D known ✓ | Q01668 | 1/20 | 0.36 |
| ▸ | CACNA1S known ✓ | Q13698 | 1/20 | 0.36 |
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL2988113 | 0.94 | TSHR (0.66) | TSHRALDH1A1THRBTAS1R3TAS1R1 | |
| Styrene SCHEMBL3291121 | 0.93 | HCAR2 (0.49) | TSHRALDH1A1HCAR2AKR1C3TAS1R3 | |
| Styrene SCHEMBL3291123 | 0.93 | HCAR2 (0.49) | TSHRALDH1A1HCAR2AKR1C3TAS1R3 | |
| Styrene SCHEMBL5832166 | 0.89 | HCAR2 (0.52) | TSHRALDH1A1HCAR2THRBLMNA | |
| Styrene SCHEMBL5832170 | 0.89 | HCAR2 (0.52) | TSHRALDH1A1HCAR2THRBLMNA | |
| Styrene SCHEMBL28739827 | 0.88 | TSHR (0.57) | TSHRALDH1A1THRBAKR1C3TAS1R3 | |
| Styrene SCHEMBL2539780 | 0.87 | TSHR (0.50) | TSHRALDH1A1HCAR2THRBTAS1R3 | |
| Styrene SCHEMBL25312124 | 0.87 | TSHR (0.53) | TSHRALDH1A1THRBTAS1R3TAS1R1 | |
| SCHEMBL7091797 | 0.85 | TSHR (0.50) | TSHRALDH1A1HCAR2THRBAKR1C3 | |
| Styrene SCHEMBL28750973 | 0.81 | TSHR (0.46) | TSHRALDH1A1THRBCACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6447973-B1 | COMPRISING A CARRIER LIQUID OF SILICON OIL, TONER PARTICLES, AND AN ERUCAMIDE COMPOUND TO PREVENT TONER FROM DEPOSITING ON THE FIXATION ROLLER | RICOH COMPANY, LTD. (JP) | 2002-09-10 | — | — | US | disclosed |