Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024590 | 0.89 | APP (0.54) | TAAR1APPHPGDADORA3ADORA2A | |
| SCHEMBL3711426 | 0.86 | HTT (0.63) | HTTKDM4ELMNAMAPTPLA2G1B | |
| SCHEMBL13650816 | 0.83 | LMNA (0.51) | HTTKDM4ELMNAMAPTPLA2G1B | |
| SCHEMBL13329874 | 0.83 | LMNA (0.66) | HTTKDM4ELMNAMAPTPLA2G1B | |
| SCHEMBL7504046 | 0.82 | SMN1; SMN2 (0.52) | HTTKDM4ELMNAMAPTAPP | |
| SCHEMBL22151175 | 0.78 | APP (0.64) | LMNATAAR1APPSMN1; SMN2ALDH1A1 | |
| SCHEMBL6672730 | 0.77 | CA12 (0.60) | LMNAAPPBCHEACHETSHR | |
| SCHEMBL12963418 | 0.77 | KMT2A (0.50) | HTTKDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL22228311 | 0.76 | KMT2A (0.73) | KDM4ESMN1; SMN2ALDH1A1HPGDMAPK1 | |
| SCHEMBL13402939 | 0.75 | HTR7 (0.59) | HTTKDM4ELMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |