SCHEMBL7589446

SCHEMBL7589446

NC(=O)C1(C(=O)O)CNCCN1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30744186 0.75
SCHEMBL2900265 0.72 ARG1 (0.39) KDM4EKMT2A
SCHEMBL27573161 0.71
SCHEMBL3033960 0.69 PKM (0.30)
SCHEMBL8109692 0.66 CES1 (0.41) KMT2A
Succinic Acid SCHEMBL5406471 0.66 ARG1 (0.37)
SCHEMBL24471489 0.66
SCHEMBL30747187 0.65 ARG1 (0.33)
SCHEMBL1068369 0.64 KDM4E (0.32) KDM4EKMT2A
SCHEMBL1068367 0.64 KDM4E (0.32) KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805803-B1 PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES LONZA AG (CH) 2002-10-30 EP claimed
EP-0805803-B1 PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES LONZA AG (CH) 2002-10-30 EP disclosed
US-5939549-A Process for the production of 1,4,5,6-tetrahydropyrazine-2-carboxylic acid amides LONZA AG (CH) 1999-08-17 US disclosed
US-5939549-A Process for the production of 1,4,5,6-tetrahydropyrazine-2-carboxylic acid amides LONZA AG (CH) 1999-08-17 US disclosed
EP-0805803-A1 PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES LONZA A.G. (CH) 1997-11-12 EP disclosed
WO-1996022981-A1 PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES LONZA AG (CH) 1996-08-01 WO disclosed