Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | CYTH2 | Q99418 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | IL1RN | P18510 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29402285 | 1.00 | ALDH1A1 (0.69) | ALDH1A1MAPTFFAR4GAAHSD17B10 | |
| SCHEMBL7588981 | 0.88 | ALDH1A1 (0.64) | ALDH1A1MAPTFFAR4GAAHSD17B10 | |
| SCHEMBL7595414 | 0.84 | ALDH1A1 (0.70) | ALDH1A1MAPTFFAR4GAACYTH2 | |
| SCHEMBL30102910 | 0.84 | ALDH1A1 (0.74) | ALDH1A1MAPTFFAR4GAATSHR | |
| SCHEMBL1116405 | 0.84 | ALDH1A1 (0.74) | ALDH1A1MAPTFFAR4GAATSHR | |
| SCHEMBL20888836 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPTFFAR4GAAHSD17B10 | |
| SCHEMBL7579963 | 0.83 | METAP2 (0.69) | ALDH1A1MAPTFFAR4GAASLC40A1 | |
| SCHEMBL578654 | 0.82 | FFAR4 (0.68) | ALDH1A1MAPTFFAR4GAAHTT | |
| SCHEMBL29472171 | 0.82 | MCL1 (0.57) | ALDH1A1MAPTFFAR4GAAHSD17B10 | |
| SCHEMBL2616424 | 0.82 | METAP2 (0.63) | ALDH1A1MAPTFFAR4GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |