SCHEMBL7589928

SCHEMBL7589928

O=C(CCc1cc(Br)cc2c(C(=O)Oc3ccccc3)c3ccc(Br)cc3nc12)ON1C(=O)CCC1=O

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PSMB8 P28062 1/20 0.33
PSMB5 P28074 1/20 0.33
MAPK1 P28482 1/20 0.32
USP7 Q93009 1/20 0.31
KMT2A Q03164 2/20 0.31
MAPT P10636 2/20 0.30
TP53 P04637 2/20 0.30
CCKBR P32239 2/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
TSHR P16473 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HTT P42858 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7581160 0.85 RXFP1 (0.36) KMT2AMAPTTP53CYP1A2KDM4E
SCHEMBL4624544 0.72 PSMB8 (0.39) PSMB8PSMB5KMT2AMAPTKDM4E
SCHEMBL10578489 0.66 KMT2A (0.48) MAPK1KMT2AMAPTTDP1KDM4E
SCHEMBL8668145 0.66 PSMB8 (0.42) PSMB8PSMB5CYP1A2TSHRKDM4E
SCHEMBL4532046 0.65 KMT2A (0.37) PSMB8PSMB5MAPK1KMT2AMAPT
SCHEMBL29666930 0.65 KMT2A (0.37) PSMB8PSMB5MAPK1KMT2AMAPT
SCHEMBL10705911 0.65 PSMB8 (0.36) PSMB8PSMB5MAPK1KMT2AMAPT
SCHEMBL21664524 0.64 CDYL (0.49) PSMB8PSMB5CYP1A2TDP1KDM4E
SCHEMBL3492697 0.64 PSMB8 (0.48) PSMB8PSMB5KMT2ACYP1A2KDM4E
SCHEMBL13920679 0.63 FFAR1 (0.42) PSMB8PSMB5KMT2ATDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1242622-A2 MONITORING OLIGONUCLEOTIDE BINDING PROCESSES USING CHEMILUMINESCENCE QUENCHING Molecular Light Technology Research Limited (GB) 2002-09-25 EP disclosed
WO-2001042497-A2 MONITORING OLIGONUCLEOTIDE BINDING PROCESSES USING CHEMILUMINESCENCE QUENCHING MOLECULAR LIGHT TECHNOLOGY RESEARCH LIMITED (GB) 2001-06-14 WO disclosed