Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17501810 | 0.84 | KDM4E (0.71) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL25722605 | 0.76 | SMN1; SMN2 (0.65) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL12490124 | 0.75 | SMN1; SMN2 (0.63) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL12293371 | 0.74 | POLB (0.62) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL13312207 | 0.73 | KDM4E (0.69) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6240207 | 0.72 | MAPK1 (0.63) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL5453917 | 0.71 | PIK3CB (0.58) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL27681005 | 0.71 | ALDH1A1 (0.63) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL9619171 | 0.71 | SMN1; SMN2 (0.57) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10418857 | 0.70 | SMN1; SMN2 (0.56) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | KDM4E 3676/4885L3MBTL1 3574/4885ALDH1A1 89/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | KDM4E 3676/4885L3MBTL1 3574/4885ALDH1A1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.