Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 4/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218939 | 0.86 | PIK3CB (0.53) | PIK3CBKMOKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL594184 | 0.80 | KMO (0.61) | PIK3CBKMOKDM4EALDH1A1NAPEPLD | |
| SCHEMBL425720 | 0.80 | KMO (0.57) | PIK3CBKMOKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1271891 | 0.80 | KMO (0.61) | KMOKDM4EALDH1A1L3MBTL1NAPEPLD | |
| SCHEMBL14818929 | 0.78 | KMT2A (0.64) | PIK3CBKDM4EALDH1A1L3MBTL1PKM | |
| SCHEMBL27700148 | 0.77 | L3MBTL1 (0.46) | PIK3CBKDM4EALDH1A1L3MBTL1PKM | |
| SCHEMBL14804579 | 0.77 | CYP1A2 (0.60) | PIK3CBKDM4EALDH1A1L3MBTL1PKM | |
| SCHEMBL3108475 | 0.76 | KMO (0.50) | PIK3CBKMOKDM4EALDH1A1PKM | |
| SCHEMBL16950261 | 0.76 | KMO (0.55) | KMOKDM4EALDH1A1L3MBTL1PKM | |
| SCHEMBL242170 | 0.75 | KMO (0.56) | PIK3CBKMOKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| CN-101023063-A | Azine-carboxamides as anti-cancer agents | ASTRAZENECA AB (SE) | 2007-08-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ARAF, BRAF, RAF1 | PIK3CB 572/4885KMO 2851/4885KDM4E 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.