Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590021 | 1.00 | DRD2 (0.38) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7583453 | 1.00 | DRD2 (0.38) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7583011 | 0.90 | HTR2C (0.38) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7586476 | 0.90 | CHRNA7 (0.40) | DRD2DRD4DRD3HRH2CYP2C19 | |
| SCHEMBL7583559 | 0.88 | CYP1A2 (0.41) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7591499 | 0.87 | TACR1 (0.39) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7584119 | 0.87 | TACR1 (0.39) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7585760 | 0.87 | TACR1 (0.39) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7583447 | 0.84 | MET (0.40) | DRD2DRD4HTR2CDRD3HTR1A | |
| SCHEMBL7584813 | 0.83 | HTR6 (0.39) | HTR2ATDP2NSD2PLA2G1BATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |