Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 11/20 | 0.75 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 7/20 | 0.56 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.55 |
| ▸ | ITGAV | P06756 | 1/20 | 0.55 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424104 | 0.92 | MMP9 (0.62) | MMP9TRPV1ALDH1A1MMP2ITGB3 | |
| SCHEMBL8193360 | 0.92 | MMP9 (0.62) | MMP9TRPV1ALDH1A1MMP2ITGB3 | |
| SCHEMBL8070197 | 0.88 | MMP9 (0.58) | MMP9TRPV1MMP2ITGB3ITGA2B | |
| SCHEMBL7583683 | 0.88 | MMP9 (0.58) | MMP9TRPV1ALDH1A1MAPTITGB3 | |
| SCHEMBL7675244 | 0.86 | MMP9 (1.00) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL7668862 | 0.86 | MMP9 (1.00) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL5093780 | 0.86 | MMP9 (1.00) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL7669356 | 0.86 | MMP9 (1.00) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL14191415 | 0.83 | MMP9 (0.93) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL14191416 | 0.83 | MMP9 (0.84) | MMP9ALDH1A1MAPTMMP2ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| EP-0757984-B1 | Hydroxamic acid derivatives useful for inhibiting gelatinase | ONO PHARMACEUTICAL CO (JP) | 2002-10-30 | — | — | EP | disclosed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| US-6022893-A | PREVENTION AND TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION OR EXCESS ACTIVATION OF GELATINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-02-08 | — | — | US | disclosed |
| EP-0757984-A1 | Hydroxamic acid derivatives useful for inhibiting gelatinase | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |