Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 10/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | MMP2 | P08253 | 9/20 | 0.62 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.58 |
| ▸ | HPN | P05981 | 1/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.58 |
| ▸ | ITGAV | P06756 | 1/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.58 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093780 | 1.00 | MMP9 (1.00) | MMP9TDP1ALDH1A1MAPTMMP2 | |
| SCHEMBL7668862 | 0.92 | MMP9 (1.00) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL7675244 | 0.92 | MMP9 (1.00) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL14191416 | 0.89 | MMP9 (0.84) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL14191415 | 0.89 | MMP9 (0.93) | MMP9ALDH1A1MAPTMMP2ADAMTS4 | |
| SCHEMBL1203540 | 0.88 | MMP2 (0.79) | MMP9TDP1ALDH1A1MAPTMMP2 | |
| SCHEMBL697476 | 0.88 | MMP2 (0.79) | MMP9TDP1ALDH1A1MAPTMMP2 | |
| SCHEMBL697477 | 0.88 | MMP2 (0.79) | MMP9TDP1ALDH1A1MAPTMMP2 | |
| Hydrochloric Acid SCHEMBL3839410 | 0.87 | MMP2 (0.77) | MMP9TDP1ALDH1A1MAPTMMP2 | |
| Hydrochloric Acid SCHEMBL11133046 | 0.87 | MMP2 (0.77) | MMP9TDP1ALDH1A1MAPTMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |