Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.45 |
| ▸ | CTSK | P43235 | 6/20 | 0.45 |
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | CTSB | P07858 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PPM1D | O15297 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CTSH | P09668 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527531 | 0.86 | CTSL (0.46) | CTSLCTSKCTSSCTSBPPM1D | |
| SCHEMBL5520844 | 0.82 | CTSS (0.67) | CTSLCTSKCTSSCTSBSMN1; SMN2 | |
| SCHEMBL5534150 | 0.82 | CTSS (0.56) | CTSLCTSKCTSSCTSBSMN1; SMN2 | |
| SCHEMBL5530575 | 0.81 | OPRM1 (0.52) | CTSLCTSKCTSSCTSBHDAC3 | |
| SCHEMBL5525360 | 0.80 | CTSL (0.50) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL5534161 | 0.80 | CTSL (0.54) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL5525335 | 0.80 | CTSL (0.69) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL5530441 | 0.80 | CTSL (0.69) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL7539158 | 0.79 | CTSL (0.55) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL5518263 | 0.79 | CTSL (0.58) | CTSLCTSKCTSSCTSBGRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455502-B1 | Compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-09-24 | — | — | US | disclosed |
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |