Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7988085 | 0.99 | PTGER1 (0.38) | PTGER1LMNAMAPTALDH1A1NPSR1 | |
| SCHEMBL7593245 | 0.85 | KDM4E (0.38) | PTGER1LMNAMAPTALDH1A1CDK2 | |
| Hydrochloric Acid SCHEMBL7508645 | 0.85 | MAPT (0.36) | PTGER1LMNAMAPTALDH1A1NPSR1 | |
| SCHEMBL7593453 | 0.85 | MEN1 (0.39) | PTGER1LMNAMAPTALDH1A1CDK2 | |
| Hydrochloric Acid SCHEMBL7990620 | 0.84 | KDM4E (0.37) | PTGER1LMNAMAPTALDH1A1CDK2 | |
| Hydrochloric Acid SCHEMBL7990631 | 0.84 | MEN1 (0.39) | PTGER1LMNAMAPTALDH1A1CDK2 | |
| Hydrochloric Acid SCHEMBL7504307 | 0.82 | ALDH1A1 (0.44) | LMNAALDH1A1KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL7499171 | 0.81 | KDM4E (0.38) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL6947129 | 0.81 | GPR84 (0.53) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6947124 | 0.80 | GPR84 (0.51) | LMNAMAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |