Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6947124 | 0.99 | GPR84 (0.51) | GPR84KDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL23084313 | 0.83 | KDM4E (0.59) | GPR84KDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL7590800 | 0.81 | PTGER1 (0.39) | KDM4EMAPTLMNAALDH1A1MEN1 | |
| SCHEMBL7593245 | 0.81 | KDM4E (0.38) | GPR84KDM4EMAPTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7507527 | 0.81 | KDM4E (0.38) | KDM4EMAPTLMNAALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7508645 | 0.81 | MAPT (0.36) | GPR84KDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL7593453 | 0.81 | MEN1 (0.39) | GPR84KDM4EMAPTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7988085 | 0.80 | PTGER1 (0.38) | KDM4EMAPTLMNAALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL7990620 | 0.80 | KDM4E (0.37) | GPR84KDM4EMAPTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7990631 | 0.80 | MEN1 (0.39) | GPR84KDM4EMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069377-A1 | DEUTERIUM-ENRICHED ENZASTAURIN | PROTIA, LLC (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069377-A1 | DEUTERIUM-ENRICHED ENZASTAURIN | PROTIA, LLC (US) | 2009-03-12 | — | — | US | disclosed |
| EP-0915872-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |
| EP-0915872-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004552-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069377-A1 | DEUTERIUM-ENRICHED ENZASTAURIN | TMPRSS15, NEK5, HDHD5 | GPR84 2603/4885KDM4E 1674/4885MAPT 3779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.