Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | C1R | P00736 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
| ▸ | ADH7 | P40394 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL96183 | 0.84 | TAAR1 (0.47) | TAAR1IDO1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL28607303 | 0.84 | ADH1B (0.36) | TAAR1CYP2D6HTR2AGPR52ADH1B | |
| SCHEMBL248640 | 0.78 | TAAR1 (0.54) | TAAR1IDO1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL27997934 | 0.78 | TAAR1 (0.71) | TAAR1IDO1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL3246427 | 0.77 | TAAR1 (0.46) | TAAR1IDO1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9642112 | 0.77 | TAAR1 (0.62) | TAAR1IDO1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL910692 | 0.76 | GABRA1 (0.39) | CYP2D6 | |
| SCHEMBL7582791 | 0.75 | ERN1 (0.34) | IDO1 | |
| SCHEMBL911043 | 0.74 | TAAR1 (0.54) | TAAR1IDO1CYP2D6 | |
| SCHEMBL4394026 | 0.74 | MAPT (0.31) | GPR52ADH1BADH1CADH1AADH7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015193910-A1 | ASYMMETRIC SYNTHESIS OF 2-SUBSTITUTED INDOLINES AND 3-SUBSTITUTED CINNOLINES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-12-23 | — | — | WO | claimed |
| CN-107438611-B | fused ring compound, pharmaceutical composition and application thereof | SHANGHAI DE NOVO PHARMATECH CO.,LTD. (CN) | 2019-10-29 | — | — | CN | disclosed |
| CN-107438611-A | fused ring compound, pharmaceutical composition and application thereof | 上海迪诺医药科技有限公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-105884828-A | Polycyclic compound, pharmaceutical composition and application thereof | 上海迪诺医药科技有限公司 | 2016-08-24 | — | — | CN | disclosed |
| WO-2015193910-A1 | ASYMMETRIC SYNTHESIS OF 2-SUBSTITUTED INDOLINES AND 3-SUBSTITUTED CINNOLINES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-12-23 | — | — | WO | disclosed |
| EP-0796618-B1 | Treatment and prophylaxis of pancreatitis | SANKYO CO (JP) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000041690-A9 | USE OF THIAZOLIDINEDIONES TO AMELIORATE THE ADVERSE CONSEQUENCES OF MYOCARDIAL ISCHEMIA ON MYOCARDIAL FUNCTION AND METABOLISM | UNIV CALIFORNIA (US) | 2001-10-11 | — | — | WO | disclosed |
| WO-2000041690-A1 | USE OF THIAZOLIDINEDIONES TO AMELIORATE THE ADVERSE CONSEQUENCES OF MYOCARDIAL ISCHEMIA ON MYOCARDIAL FUNCTION AND METABOLISM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-07-20 | — | — | WO | disclosed |
| US-5968960-A | ANTIISCHEMIC AGENTS AND HYPOTENSIVE AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-10-19 | — | — | US | disclosed |
| US-5804590-A | ADMINISTERING DERIVATIVES OF THIAZOLIDINE; ANTI-DIABETIC AGENTS. | SANKYO COMPANY, LIMITED (JP) | 1998-09-08 | — | — | US | disclosed |
| US-5753681-A | INSULIN SENSITIZERS | SANKYO COMPANY, LIMITED (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0796618-A1 | Treatment and prophylaxis of pancreatitis | SANKYO COMPANY LIMITED (JP) | 1997-09-24 | — | — | EP | disclosed |
| EP-0783888-A1 | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis | SANKYO COMPANY LIMITED (JP) | 1997-07-16 | — | — | EP | disclosed |