Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.39 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31053746 | 1.00 | CES2 (0.46) | CES2RXRARXRBRXRGMGLL | |
| SCHEMBL28549368 | 0.87 | CES2 (0.47) | CES2RXRARXRBRXRGMGLL | |
| SCHEMBL28949758 | 0.85 | CES2 (0.46) | CES2RXRARXRBRXRGMGLL | |
| SCHEMBL30705412 | 0.81 | MGLL (0.39) | CES2MGLLTRPV6ORAI1ORAI2 | |
| SCHEMBL2412562 | 0.81 | PDE2A (0.42) | MGLLTRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL31351020 | 0.81 | PDE2A (0.42) | MGLLTRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL28024774 | 0.81 | MRGPRX4 (0.43) | MGLLTRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL30916840 | 0.80 | MRGPRX4 (0.44) | CYP2C19RAB9AL3MBTL1KDM4EPTGDR2 | |
| SCHEMBL2415029 | 0.80 | MRGPRX4 (0.45) | — | |
| SCHEMBL31072357 | 0.79 | MAPT (0.43) | TRPV6ORAI1ORAI2ORAI3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |