Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL759935 | 0.85 | NPBWR1 (0.44) | PKMALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL30843270 | 0.79 | KMT2A (0.42) | ALDH1A1SMN1; SMN2KDM4EFAAHMEN1 | |
| SCHEMBL21458311 | 0.79 | KMT2A (0.42) | ALDH1A1SMN1; SMN2KDM4EFAAHMEN1 | |
| SCHEMBL10214813 | 0.79 | AURKA (0.47) | NPC1RAB9ALMNALRRK2ALDH1A1 | |
| SCHEMBL25375332 | 0.77 | NPBWR1 (0.44) | ALDH1A1SMN1; SMN2FAAHMEN1KMT2A | |
| SCHEMBL23938744 | 0.76 | NPBWR1 (0.46) | LMNAPKMALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14404449 | 0.75 | GAA (0.39) | NPC1RAB9ALMNAALDH1A1MAPT | |
| SCHEMBL18301358 | 0.74 | NPBWR1 (0.44) | PKM | |
| SCHEMBL25376545 | 0.74 | PTGDR2 (0.41) | ALDH1A1SMN1; SMN2FAAHMEN1KMT2A | |
| SCHEMBL30552936 | 0.72 | KDM4E (0.46) | NPC1RAB9ALMNAPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | NPC1 58/4885RAB9A 740/4885LMNA 3544/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | NPC1 58/4885RAB9A 740/4885LMNA 3544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.