Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386967 | 0.94 | MAPT (0.44) | MAPTTHRBPOLBTP53USP2 | |
| SCHEMBL7389136 | 0.89 | SIGMAR1 (0.46) | MAPTTHRBPOLBLMNATSHR | |
| SCHEMBL7381271 | 0.89 | SIGMAR1 (0.46) | MAPTTHRBPOLBLMNAGAA | |
| SCHEMBL7383868 | 0.89 | THRB (0.44) | MAPTTHRBPOLBTP53LMNA | |
| SCHEMBL7379080 | 0.89 | THRB (0.45) | MAPTTHRBPOLBTP53USP2 | |
| SCHEMBL7389681 | 0.89 | THRB (0.46) | MAPTTHRBPOLBTP53LMNA | |
| SCHEMBL7388647 | 0.88 | MAPT (0.48) | MAPTTHRBPOLBTP53LMNA | |
| SCHEMBL7388914 | 0.88 | THRB (0.46) | MAPTTHRBLMNASIGMAR1MAOA | |
| SCHEMBL7388548 | 0.88 | MAPT (0.45) | MAPTTHRBPOLBTP53LMNA | |
| SCHEMBL7388713 | 0.87 | THRB (0.46) | MAPTTHRBPOLBLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |