SCHEMBL7593142

SCHEMBL7593142

CCC(C)Cc1cc(NC(=S)Nc2cc[c]cc2)cc(C(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MYC P01106 1/20 0.42
MAX P61244 1/20 0.42
ALDH1A1 P00352 5/20 0.40
HTT P42858 2/20 0.40
MAPT P10636 8/20 0.40
KDM4E B2RXH2 2/20 0.40
MEN1 O00255 5/20 0.39
KMT2A Q03164 5/20 0.39
LMNA P02545 2/20 0.39
SMN1; SMN2 Q16637 3/20 0.38
GAA P10253 4/20 0.38
PSMB5 P28074 1/20 0.38
NPY1R P25929 1/20 0.37
NPSR1 Q6W5P4 2/20 0.37
TDP1 Q9NUW8 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7743522 0.86 MAPT (0.43) MYCMAXALDH1A1HTTMAPT
SCHEMBL7645182 0.83 ALDH1A1 (0.44) MYCMAXALDH1A1HTTMAPT
SCHEMBL7569356 0.80 MAPT (0.57) MYCMAXALDH1A1MAPTKDM4E
SCHEMBL7593149 0.79 UBE2M (0.40) ALDH1A1MAPTCYP1A2
SCHEMBL6811866 0.79 TLR8 (0.50) MYCMAXALDH1A1MAPTKDM4E
SCHEMBL6811101 0.77 MAPT (0.56) ALDH1A1MAPTMEN1KMT2ALMNA
SCHEMBL7866871 0.76 GAA (0.44) MYCMAXHTTMAPTKDM4E
SCHEMBL7569409 0.75 MAPT (0.45) MYCMAXALDH1A1HTTMAPT
SCHEMBL7075937 0.74 ALDH1A1 (0.43) ALDH1A1MAPTLMNAGAA
SCHEMBL7569403 0.72 ALDH1A1 (0.47) MYCMAXALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144399-A3 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP Wyeth (US) 2002-09-11 EP disclosed
EP-1144399-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-17 EP disclosed
WO-2000034261-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed