Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330944 | 0.88 | KDM4E (0.65) | DNM1MEN1KMT2ATP53MAPK1 | |
| Sulfuric Acid SCHEMBL28266560 | 0.86 | DNM1 (0.49) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL3895000 | 0.85 | LMNA (0.47) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL8894036 | 0.84 | DNM1 (0.50) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL9321980 | 0.84 | DNM1 (0.44) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL330483 | 0.84 | DNM1 (0.79) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL330707 | 0.84 | DNM1 (0.79) | DNM1MEN1KMT2ATP53MAPK1 | |
| Benzododecinium SCHEMBL330693 | 0.84 | DNM1 (0.79) | DNM1MEN1KMT2ATP53MAPK1 | |
| Trifluoromethanesulfonic Acid SCHEMBL30851370 | 0.83 | KDM4E (0.44) | DNM1MEN1KMT2ATP53MAPK1 | |
| SCHEMBL374778 | 0.82 | ALDH1A1 (0.67) | DNM1MEN1KMT2ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728743-B1 | 3-Amino-tetrahydrocarbazol propanoic acid esters | BAYER AG (DE) | 2002-10-30 | — | — | EP | disclosed |
| US-5684158-A | 3-amino!-tetrahydrocarbazole-propanoic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1997-11-04 | — | — | US | disclosed |
| EP-0728743-A1 | 3-Amino-tetrahydrocarbazol propanoic acid esters | BAYER AG (DE) | 1996-08-28 | — | — | EP | disclosed |