Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 11/20 | 0.46 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593521 | 0.89 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C19CYP2D6HCAR3 | |
| SCHEMBL7593083 | 0.87 | HCAR3 (0.47) | ALDH1A1CYP3A4CYP2C19HCAR3KMT2A | |
| SCHEMBL27845365 | 0.86 | HCAR3 (0.58) | ALDH1A1HCAR3KMT2AMAPTMEN1 | |
| SCHEMBL27751822 | 0.83 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C19HCAR3MAPT | |
| SCHEMBL2352024 | 0.81 | NEU3 (0.51) | ALDH1A1HCAR3NEU3KMT2AMAPT | |
| SCHEMBL7596912 | 0.80 | NEU3 (0.54) | ALDH1A1NEU3KMT2AMAPTMEN1 | |
| SCHEMBL3343373 | 0.79 | NEU3 (0.55) | ALDH1A1HCAR3NEU3KMT2AMAPT | |
| SCHEMBL5063149 | 0.79 | TSHR (0.55) | ALDH1A1CYP3A4CYP2C19HCAR3KMT2A | |
| SCHEMBL2340516 | 0.78 | NEU3 (0.54) | ALDH1A1NEU3KMT2AMAPTMEN1 | |
| SCHEMBL10739453 | 0.78 | NEU3 (0.48) | ALDH1A1NEU3KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020082280-A1 | Method of inhibiting neoplastic cells with benzimidazole derivatives | OSI PHARMACEUTICALS, INC. | 2002-06-27 | — | — | US | disclosed |
| US-6348032-B1 | POTENT COMPOUNDS THAT INDUCE APOPTOSIS IN NEOPLASTIC CELLS (BUT NOT SUBSTANTIALLY IN NORMAL CELLS), WITHOUT SUBSTANTIALLY INHIBITING PGE-2. | CELL PATHWAYS, INC. | 2002-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082280-A1 | Method of inhibiting neoplastic cells with benzimidazole derivatives | MKI67, CCNI, TMBIM6 | ALDH1A1 487/4885CYP3A4 1001/4885CYP2C19 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.