⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11659916 | 0.78 | ALDH1A1 (0.45) | — | |
| SCHEMBL19543108 | 0.75 | — | — | |
| SCHEMBL16591048 | 0.75 | TSHR (0.37) | — | |
| SCHEMBL4195938 | 0.75 | ALDH1A1 (0.32) | — | |
| SCHEMBL2775798 | 0.75 | ALDH1A1 (0.35) | — | |
| SCHEMBL9156371 | 0.75 | MMP1 (0.31) | — | |
| SCHEMBL14274518 | 0.73 | — | — | |
| SCHEMBL15277624 | 0.73 | — | — | |
| SCHEMBL23978886 | 0.73 | — | — | |
| SCHEMBL23978866 | 0.73 | TSHR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620458-B1 | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-alpha-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING 3,3-DIMETHYLBUTYRALDEHYDE DIMETHYL ACETAL AS A PRECURSOR | NUTRASWEET PROPERTY HOLDINGS INC (US) | 2012-03-21 | — | — | EP | claimed |
| US-7288670-B2 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors | THE NUTRASWEET COMPANY (US) | 2007-10-30 | — | — | US | claimed |
| EP-1620458-A2 | SYNTHESIS OF N- [N-(3,3-DIMETHYLBUTYL)-L-a-ASPARTYL] -L-PHENYLALANINE 1-METHYL ESTER USING 3,3-DIMETHYLBUTYRALDEHYDE PRECURSORS | The NutraSweet Company (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004101604-A2 | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING 3,3-DIMETHYLBUTYRALDEHYDE PRECURSORS | NUTRASWEET COMPANY (US) | 2004-11-25 | — | — | WO | claimed |
| US-20040236140-A1 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors | NUTRASWEET COMPANY | 2004-11-25 | — | — | US | claimed |
| US-20170275243-A1 | Lipids and Lipid Compositions for the Delivery of Active Agents | NOVARTIS AG (CH) | 2017-09-28 | — | — | US | disclosed |
| US-20170196809-A1 | METHOD OF ENCAPSULATING A NUCLEIC ACID IN A LIPID NANOPARTICLE HOST | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-07-13 | — | — | US | disclosed |
| US-20160317458-A1 | Lipids and Lipid Compositions for the Delivery of Active Agents | NOVARTIS AG (CH) | 2016-11-03 | — | — | US | disclosed |
| US-20160311759-A1 | Lipids and Lipid Compositions for the Delivery of Active Agents | NOVARTIS AG (CH) | 2016-10-27 | — | — | US | disclosed |
| EP-2275401-B1 | Crystalline 1-{[(alpha-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid | XENOPORT INC (US) | 2013-04-03 | — | — | EP | disclosed |
| US-8309552-B2 | Immunomodulating heterocyclic compounds | MEDIGENE AG (DE) | 2012-11-13 | — | — | US | disclosed |
| EP-1620458-B1 | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-alpha-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING 3,3-DIMETHYLBUTYRALDEHYDE DIMETHYL ACETAL AS A PRECURSOR | NUTRASWEET PROPERTY HOLDINGS INC (US) | 2012-03-21 | — | — | EP | disclosed |
| US-7288670-B2 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors | THE NUTRASWEET COMPANY (US) | 2007-10-30 | — | — | US | disclosed |
| US-7276505-B2 | Immunomodulating heterocyclic compounds | MEDIGENE LIMITED (GB) | 2007-10-02 | — | — | US | disclosed |
| US-7276505-B2 | Immunomodulating heterocyclic compounds | MEDIGENE LIMITED (GB) | 2007-10-02 | — | — | US | disclosed |
| US-20070021428-A1 | Immunomodulating heterocyclic compounds | AVIDEX LIMITED (GB) | 2007-01-25 | — | — | US | disclosed |
| US-20070021428-A1 | Immunomodulating heterocyclic compounds | AVIDEX LIMITED (GB) | 2007-01-25 | — | — | US | disclosed |
| EP-1620458-A2 | SYNTHESIS OF N- [N-(3,3-DIMETHYLBUTYL)-L-a-ASPARTYL] -L-PHENYLALANINE 1-METHYL ESTER USING 3,3-DIMETHYLBUTYRALDEHYDE PRECURSORS | The NutraSweet Company (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004101604-A2 | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING 3,3-DIMETHYLBUTYRALDEHYDE PRECURSORS | NUTRASWEET COMPANY (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040236140-A1 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors | NUTRASWEET COMPANY | 2004-11-25 | — | — | US | disclosed |