SCHEMBL7594082

SCHEMBL7594082

Cc1cccc2c1C(C(=O)Oc1c(F)ccc(F)c1F)c1ccccc1N2

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 3/20 0.33
SLC6A2 P23975 2/20 0.33
SLC6A4 P31645 2/20 0.33
CYP2D6 P10635 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
TP53 P04637 1/20 0.32
GAA P10253 1/20 0.31
HDAC4 P56524 1/20 0.30
HTR1A P08908 1/20 0.30
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7590468 0.86 PBRM1 (0.36) MAPTL3MBTL1ALDH1A1SLC6A2SLC6A4
SCHEMBL7588820 0.79 HDAC4 (0.40) MAPTL3MBTL1GAAHDAC4EGFR
SCHEMBL8332484 0.76 PIN1 (0.38) MAPTL3MBTL1ALDH1A1KDM4ENPC1
SCHEMBL3855902 0.75 ALDH1A1 (0.45) MAPTL3MBTL1ALDH1A1KDM4ENPC1
SCHEMBL8686697 0.75 PIN1 (0.32) MAPTL3MBTL1ALDH1A1KDM4ENPC1
SCHEMBL8686287 0.73 MEN1 (0.38) MAPTL3MBTL1GAAHDAC4EGFR
Acridan SCHEMBL6342017 0.73 HDAC4 (0.38) MAPTL3MBTL1ALDH1A1KDM4ESLC6A2
SCHEMBL3859311 0.69 HDAC4 (0.48) MAPTL3MBTL1ALDH1A1SLC6A2SLC6A4
SCHEMBL29382936 0.69 HDAC4 (0.48) MAPTL3MBTL1ALDH1A1SLC6A2SLC6A4
SCHEMBL7591257 0.69 HDAC4 (0.40) MAPTL3MBTL1ALDH1A1KDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778946-B1 NOVEL METHOD AND KITS FOR PRODUCING LIGHT FROM AN ACRIDAN COMPOUND LUMIGEN INC (US) 2002-10-23 EP disclosed
EP-0778946-A4 NOVEL METHOD AND KITS FOR PRODUCING LIGHT FROM AN ACRIDAN COMPOUND LUMIGEN INC (US) 1999-01-27 EP disclosed
US-5723295-A MULTISTAGE CHEMILUMINESCENT ASSAY WITH PEROXIDASE ENZYME, PH ADJUSTMENT LUMIGEN, INC. (US) 1998-03-03 US disclosed
US-5670644-A CHEMILUMINESCENT REACTIONS, PEROXIDASE AND PH FOR IMMUNOASSAY LUMIGEN, INC. (US) 1997-09-23 US disclosed
EP-0778946-A1 NOVEL METHOD AND KITS FOR PRODUCING LIGHT FROM AN ACRIDAN COMPOUND LUMIGEN, INC. (US) 1997-06-18 EP disclosed
WO-1996007912-A1 NOVEL METHOD AND KITS FOR PRODUCING LIGHT FROM AN ACRIDAN COMPOUND LUMIGEN, INC. (US) 1996-03-14 WO disclosed