Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597986 | 0.91 | PTPN1 (0.35) | PPARDEPHX1 | |
| SCHEMBL7193736 | 0.82 | PTPN1 (0.38) | ALDH1A1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL7598595 | 0.81 | EPHX1 (0.33) | EPHX1 | |
| SCHEMBL7188479 | 0.80 | MAOA (0.41) | ALDH1A1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL7592123 | 0.80 | EPHX1 (0.36) | ALDH1A1EPHX1 | |
| SCHEMBL7204587 | 0.79 | PTPN1 (0.35) | ALDH1A1MAPTEPHX1PKM | |
| SCHEMBL7596322 | 0.79 | PTPN1 (0.35) | ALDH1A1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL7594144 | 0.77 | PTPN1 (0.50) | EPHX1 | |
| SCHEMBL7592249 | 0.77 | ALDH1A1 (0.35) | ALDH1A1MAPTEPHX1PKM | |
| SCHEMBL7187616 | 0.77 | LMNA (0.33) | ALDH1A1CYP1A2MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | PTPRF, PTPRS, PTPRO | PPARD 557/4885ALDH1A1 312/4885CYP1A2 2543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.