Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Dihydrospingosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.82 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.82 |
| ▸ | GMNN | O75496 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | THPO | P40225 | 1/20 | 0.82 |
| ▸ | MTOR | P42345 | 1/20 | 0.82 |
| ▸ | BLM | P54132 | 1/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | CETP | P11597 | 1/20 | 0.82 |
| ▸ | HTT | P42858 | 1/20 | 0.82 |
| ▸ | UBE2N | P61088 | 1/20 | 0.82 |
| ▸ | LAP3 | P28838 | 2/20 | 0.55 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrospingosine SCHEMBL30473323 | 1.00 | CYP2D6 (0.82) | CYP2D6SPHK1GMNNLMNAPOLB | |
| Dihydrospingosine SCHEMBL13285654 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL1901499 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL1907293 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL8746720 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| Dihydrospingosine SCHEMBL1905632 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| Dihydrospingosine SCHEMBL7106054 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL21660227 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL21431064 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB | |
| Dihydrospingosine SCHEMBL3509781 | 0.91 | CYP2D6 (1.00) | CYP2D6SPHK1GMNNLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768328-A1 | GENE REGULATION VIA CONDITIONAL NUCLEAR LOCALIZATION OF GENE MODULATING POLYPEPTIDES | Refuge Biotechnologies, Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183572-A1 | GENE REGULATION VIA CONDITIONAL NUCLEAR LOCALIZATION OF GENE MODULATING POLYPEPTIDES | REFUGE BIOTECHNOLOGIES, INC. (US) | 2019-09-26 | — | — | WO | disclosed |
| WO-2018175480-A1 | METHODS OF INHIBITING FUNGAL CERAMIDE SYNTHASE FOR TREATMENT OF CRYPTOCOCCUS NEOFORMANS INFECTION | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-09-27 | — | — | WO | disclosed |
| US-20170198308-A1 | Chimeric Proteins and Methods of Regulating Gene Expression | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2017-07-13 | — | — | US | disclosed |
| EP-1257559-A1 | MAMMALIAN SPHINGOSINE-1-PHOSPHATE PHOSPHATASE | Merck & Co., Inc. (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001057057-A1 | MAMMALIAN SPHINGOSINE-1-PHOSPHATE PHOSPHATASE | MERCK & CO., INC. (US) | 2001-08-09 | — | — | WO | disclosed |
| WO-1995021848-A1 | SPHINGOID BASES AND METHODS FOR THEIR PREPARATION AND USE | THE UNITED STATES OF AMERICA, REPRESENTED BY THE (US) | 1995-08-17 | — | — | WO | disclosed |