Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hymecromone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.87 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.87 |
| ▸ | CA12 | O43570 | 5/20 | 0.87 |
| ▸ | CA9 | Q16790 | 5/20 | 0.87 |
| ▸ | HPGD | P15428 | 5/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.87 |
| ▸ | GLA | P06280 | 4/20 | 0.87 |
| ▸ | GAA | P10253 | 4/20 | 0.87 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.87 |
| ▸ | MAOB | P27338 | 3/20 | 0.87 |
| ▸ | CASP1 | P29466 | 2/20 | 0.87 |
| ▸ | CASP7 | P55210 | 2/20 | 0.87 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.87 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.87 |
| ▸ | KDR | P35968 | 1/20 | 0.87 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hymecromone SCHEMBL29364837 | 0.93 | HSD17B3 (1.00) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL29624431 | 0.93 | HSD17B3 (1.00) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL2357040 | 0.93 | HSD17B3 (1.00) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL24150 | 0.93 | HSD17B3 (1.00) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL27924142 | 0.92 | HSD17B3 (0.96) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL31014 | 0.92 | HSD17B3 (0.96) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL29176761 | 0.90 | ALDH1A1 (0.87) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL27728511 | 0.90 | HSD17B3 (0.93) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL2256610 | 0.89 | ALDH1A1 (0.90) | KDM4EALDH1A1HSD17B3CA12CA9 | |
| Hymecromone SCHEMBL1459406 | 0.88 | KDM4E (0.77) | KDM4EALDH1A1HSD17B3CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117871508-A | Reagent card for rapidly detecting pesticide residues and pesticide residue detection method | 苏州慧源安食检测科技有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-115298548-A | Method for detecting viruses having hemagglutinin esterase activity | 李知勋 | 2022-11-04 | — | — | CN | claimed |
| CN-110596083-B | Reagent and card for detecting organophosphorus and carbamate pesticide residues | 广州聚佰生物科技有限公司 | 2021-10-15 | — | — | CN | claimed |
| CN-110596083-A | Reagent and card for detecting organophosphorus and carbamate pesticide residues | 广州聚佰生物科技有限公司 | 2019-12-20 | — | — | CN | claimed |
| CN-117871508-A | Reagent card for rapidly detecting pesticide residues and pesticide residue detection method | 苏州慧源安食检测科技有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-116850314-A | Liquid-chemical sterilization system with biological indicator | 爱思帕全球制造有限公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-113453728-B | Liquid-chemical sterilization system with biological indicator | 爱思帕全球制造有限公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-116194158-A | Biological indicator comprising genetically modified test microorganism | 3M创新有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-115461468-A | Biological indicator with test microorganisms encapsulated by wax composition | 3M创新有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-115315522-A | Fixed pH indicator for biological indicator growth indication | 3M创新有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-115298548-A | Method for detecting viruses having hemagglutinin esterase activity | 李知勋 | 2022-11-04 | — | — | CN | disclosed |
| CN-114981399-A | Self-contained biological indicator with salt compound | 3M创新有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-109985267-B | Self-contained biological indicator | 伊西康公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-113543760-A | Biological indicator for liquid chemical disinfection system | 爱思帕全球制造有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-110596083-B | Reagent and card for detecting organophosphorus and carbamate pesticide residues | 广州聚佰生物科技有限公司 | 2021-10-15 | — | — | CN | disclosed |
| CN-113166795-A | Method for detecting specific nucleic acid | 西门子医疗有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-112437676-A | Self-contained biological indicator | 3M创新有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-110596083-A | Reagent and card for detecting organophosphorus and carbamate pesticide residues | 广州聚佰生物科技有限公司 | 2019-12-20 | — | — | CN | disclosed |
| WO-2002099041-A2 | CES2S AS MODIFIERS OF THE P53 PATHWAY AND METHODS OF USE | EXELIXIS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |