Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.90 |
| ▸ | HPGD | P15428 | 6/20 | 0.90 |
| ▸ | GAA | P10253 | 6/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.90 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.90 |
| ▸ | GLA | P06280 | 5/20 | 0.90 |
| ▸ | CA12 | O43570 | 3/20 | 0.90 |
| ▸ | CA9 | Q16790 | 3/20 | 0.90 |
| ▸ | CASP1 | P29466 | 2/20 | 0.90 |
| ▸ | CASP7 | P55210 | 2/20 | 0.90 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.90 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.90 |
| ▸ | MAOB | P27338 | 2/20 | 0.90 |
| ▸ | LMNA | P02545 | 1/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.90 |
| ▸ | KDR | P35968 | 1/20 | 0.90 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hymecromone SCHEMBL29364837 | 0.95 | HSD17B3 (1.00) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL24150 | 0.95 | HSD17B3 (1.00) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL29624431 | 0.95 | HSD17B3 (1.00) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL2357040 | 0.95 | HSD17B3 (1.00) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL31014 | 0.93 | HSD17B3 (0.96) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL27924142 | 0.93 | HSD17B3 (0.96) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL27728511 | 0.92 | HSD17B3 (0.93) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL7594956 | 0.89 | KDM4E (0.87) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL28882003 | 0.89 | KDM4E (0.87) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| Hymecromone SCHEMBL720434 | 0.89 | KDM4E (0.87) | ALDH1A1KDM4EHPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200188431-A1 | GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2020-06-18 | — | — | US | claimed |
| EP-3635115-A1 | GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION | VIB VZW (BE) | 2020-04-15 | — | — | EP | claimed |
| WO-2018224636-A1 | GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION | VIB VZW (BE) | 2018-12-13 | — | — | WO | claimed |
| US-20200188431-A1 | GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2020-06-18 | — | — | US | disclosed |
| EP-3635115-A1 | GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION | VIB VZW (BE) | 2020-04-15 | — | — | EP | disclosed |
| WO-2018224636-A1 | GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION | VIB VZW (BE) | 2018-12-13 | — | — | WO | disclosed |
| US-20180042899-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| US-8772252-B2 | Coumarin compounds as melanogenesis modifiers and uses thereof | NEW YORK UNIVERSITY (US) | 2014-07-08 | — | — | US | disclosed |
| US-20140050694-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-02-20 | — | — | US | disclosed |
| US-8563754-B2 | Compounds, compositions and methods for preventing skin darkening | NEW YORK UNIVERSITY (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120220545-A1 | COUMARIN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF | NEW YORK UNIVERSITY | 2012-08-30 | — | — | US | disclosed |
| US-20110190229-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING | NEW YORK UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
| US-20090269772-A1 | SYSTEMS AND METHODS FOR IDENTIFYING COMBINATIONS OF COMPOUNDS OF THERAPEUTIC INTEREST | THERASIS, INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220545-A1 | COUMARIN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF | TYR, MC1R, MITF | ALDH1A1 246/4885KDM4E 79/4885HPGD 2055/4885 |
| US-20200188431-A1 | GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION | GLUL, GLS2, GLS | ALDH1A1 312/4885KDM4E 864/4885HPGD 150/4885 |
| US-20110190229-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING | TYR, MC1R, MITF | ALDH1A1 397/4885KDM4E 274/4885HPGD 574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.