Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 10/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7577106 | 0.85 | CXCR2 (0.52) | CXCR2POLBKDM4EALDH1A1HPGD | |
| SCHEMBL7586739 | 0.85 | CXCR2 (0.47) | CXCR2POLBMEN1KMT2AGRIK1 | |
| SCHEMBL3206570 | 0.83 | GRIK1 (0.49) | CXCR2ALDH1A1MEN1KMT2AGRIK1 | |
| SCHEMBL28277843 | 0.79 | MEN1 (0.57) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3364068 | 0.79 | POLB (0.60) | CXCR2POLBKDM4EALDH1A1HPGD | |
| SCHEMBL28277832 | 0.74 | POLB (0.44) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL22719750 | 0.74 | MEN1 (0.60) | ALDH1A1MEN1KMT2AGRIK1LMNA | |
| SCHEMBL7573159 | 0.72 | CXCR2 (0.47) | CXCR2ALDH1A1MEN1KMT2AGRIK1 | |
| SCHEMBL7571639 | 0.71 | CXCR2 (0.49) | CXCR2POLBALDH1A1MEN1KMT2A | |
| SCHEMBL28276372 | 0.71 | KDM4E (0.65) | CXCR2POLBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117633-B1 | DIAMINOCYCLOBUTENE-3,4-DIONE DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH AS (DK) | 2002-09-18 | — | — | EP | disclosed |
| US-6413996-B2 | CHLORIDE CHANNEL BLOCKERS; FOR TREATMENT OF SICKLE CELL ANAEMIA, BRAIN OEDEMA FOLLOWING ISCHAEMIA OR TUMOURS, DIARRHOEA, HYPERTENSION (DIURETIC), OSTEOPOROSIS, BONE METASTASIZING CANCERS | NEUROSEARCH A/S (DK) | 2002-07-02 | — | — | US | disclosed |
| US-20010056092-A1 | Diaminocyclobutene-3,4-dione derivatives, their preparation and use | ANIONA APS (DK) | 2001-12-27 | — | — | US | disclosed |
| EP-1117633-A1 | DIAMINOCYCLOBUTENE-3,4-DIONE DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000020378-A1 | DIAMINOCYCLOBUTENE-3,4-DIONE DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 2000-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010056092-A1 | Diaminocyclobutene-3,4-dione derivatives, their preparation and use | HCN4, CLIC1, KCNB1 | CXCR2 415/4885POLB 2087/4885KDM4E 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.