Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | RHOA | P61586 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651297 | 0.86 | THRB (0.41) | PGRTHRBTDP1APEX1NPSR1 | |
| SCHEMBL6771024 | 0.76 | THRB (0.39) | PGRTHRBTDP1APEX1NPSR1 | |
| SCHEMBL7600166 | 0.76 | MTTP (0.38) | — | |
| SCHEMBL9610538 | 0.75 | ELANE (0.34) | PGRNPSR1CYP3A4ALDH1A1MAPT | |
| SCHEMBL19335203 | 0.75 | MAPT (0.34) | PGRNPSR1CYP3A4ALDH1A1MAPT | |
| SCHEMBL7595150 | 0.73 | APEX1 (0.37) | THRBTDP1APEX1ALDH1A1MAPT | |
| SCHEMBL5864017 | 0.70 | THRB (0.48) | PGRTHRBTDP1APEX1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6771034 | 0.69 | THRB (0.47) | PGRTHRBTDP1APEX1ALDH1A1 | |
| SCHEMBL22678704 | 0.69 | PDK2 (0.42) | PGRTHRBTDP1APEX1ALDH1A1 | |
| SCHEMBL88451 | 0.68 | PGR (0.49) | PGRTHRBTDP1APEX1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |