Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373141 | 0.92 | KMT2A (0.51) | MEN1KMT2AITGB3ITGA2BNPC1 | |
| SCHEMBL2833035 | 0.79 | ITGB3 (0.48) | MEN1KMT2AITGB3ITGA2BLMNA | |
| SCHEMBL8371218 | 0.78 | ITGB3 (0.61) | MEN1KMT2AITGB3ITGA2BTHRB | |
| SCHEMBL6368243 | 0.78 | ITGB3 (0.57) | MEN1KMT2AITGB3ITGA2BALDH1A1 | |
| SCHEMBL9303041 | 0.78 | PLAU (0.61) | MEN1KMT2AITGB3ITGA2BKCNK3 | |
| SCHEMBL7864209 | 0.78 | HPSE (0.62) | MEN1KMT2AITGB3ITGA2BALDH1A1 | |
| SCHEMBL6368868 | 0.77 | LMNA (0.53) | MEN1KMT2ALMNASMN1; SMN2NPC1 | |
| SCHEMBL6368621 | 0.77 | ITGB3 (0.46) | MEN1KMT2AITGB3ITGA2BLMNA | |
| SCHEMBL6367010 | 0.77 | ITGB3 (0.46) | MEN1KMT2AITGB3ITGA2BLMNA | |
| SCHEMBL7378119 | 0.77 | MEN1 (0.47) | MEN1KMT2AITGB3ITGA2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |