Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572736 | 0.80 | TP53 (0.59) | TP53HPGDALDH1A1KDM4EHTT | |
| SCHEMBL7590525 | 0.79 | NPC1 (0.63) | TP53HPGDALDH1A1KDM4EHTT | |
| SCHEMBL10192087 | 0.79 | HTT (0.88) | TP53HPGDALDH1A1HTTKMT2A | |
| SCHEMBL29031229 | 0.79 | MEN1 (0.77) | HPGDALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL7594332 | 0.77 | ALDH1A1 (0.71) | TP53ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL1164889 | 0.76 | CYP2D6 (0.62) | TP53HPGDALDH1A1KDM4EHTT | |
| SCHEMBL16383840 | 0.76 | HPGD (0.54) | TP53HPGDALDH1A1KDM4EHTT | |
| SCHEMBL24254325 | 0.76 | CYP2D6 (0.67) | HPGDALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL4709087 | 0.76 | MEN1 (0.84) | TP53HPGDALDH1A1KDM4EHTT | |
| SCHEMBL259416 | 0.75 | HPGD (1.00) | TP53HPGDALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |