Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23308739 | 0.82 | HTT (0.46) | MKNK1MKNK2HTTMAPK1POLB | |
| SCHEMBL2396567 | 0.76 | TDO2 (0.42) | MKNK1MKNK2MAPK1SMN1; SMN2GABRP | |
| SCHEMBL3417306 | 0.75 | HTT (0.73) | MKNK1MKNK2HTTPOLBFGFR1 | |
| SCHEMBL5686122 | 0.73 | GSK3B (0.74) | GSK3B | |
| SCHEMBL21163405 | 0.73 | ADRB1 (0.39) | MKNK1MKNK2HTTMAPK1POLB | |
| SCHEMBL2186557 | 0.72 | HCAR1 (0.56) | MKNK1MKNK2HTTMAPK1POLB | |
| SCHEMBL30955935 | 0.72 | HCAR1 (0.56) | MKNK1MKNK2HTTMAPK1POLB | |
| SCHEMBL30524297 | 0.72 | HTT (0.62) | MKNK1MKNK2HTTMAPK1POLB | |
| SCHEMBL5686043 | 0.72 | SIRT2 (0.62) | MKNK1MKNK2GSK3BMAPT | |
| SCHEMBL311147 | 0.72 | MAPK1 (0.52) | MKNK1MKNK2HTTMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106220611-A | The new preparation process of 2 (1H indole 3 base) 1H benzimidizole derivatives | 青岛科技大学 | 2016-12-14 | — | — | CN | claimed |
| CN-106220611-A | The new preparation process of 2 (1H indole 3 base) 1H benzimidizole derivatives | 青岛科技大学 | 2016-12-14 | — | — | CN | disclosed |
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |
| US-5886008-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0666858-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1?) AGONISTS | PFIZER INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010171-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT1) AGONISTS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |