SCHEMBL759682

SCHEMBL759682

COc1ccc(C2(c3ccc(OC(=O)Oc4cccc(-n5c(=O)c6cc7c(=O)n(-c8cccc(OC(C)=O)c8)c(=O)c7cc6c5=O)c4)cc3)CCCCC2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.43
KMT2A Q03164 4/20 0.40
ALDH1A1 P00352 3/20 0.40
MEN1 O00255 2/20 0.40
HTT P42858 1/20 0.40
HSD17B10 Q99714 1/20 0.40
MAPT P10636 2/20 0.39
KDM4E B2RXH2 1/20 0.39
CYP2C9 P11712 1/20 0.39
HPGD P15428 1/20 0.39
TP53 P04637 1/20 0.38
POLB P06746 1/20 0.37
CACNA1B Q00975 1/20 0.36
APBA1 Q02410 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
CYP2C19 P33261 1/20 0.35
PKM P14618 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL760402 0.92 NPSR1 (0.49) NPSR1KMT2AALDH1A1HTTMAPT
SCHEMBL19194913 0.82 KMT2A (0.51) KMT2AALDH1A1MEN1MAPTKDM4E
SCHEMBL759685 0.81 NPSR1 (0.47) NPSR1KMT2AALDH1A1MEN1HTT
SCHEMBL760381 0.79 HSD17B10 (0.56) KMT2AALDH1A1MEN1HSD17B10MAPT
SCHEMBL13986180 0.79 KMT2A (0.48) KMT2AALDH1A1MEN1MAPTKDM4E
SCHEMBL12919554 0.79 KMT2A (0.48) KMT2AMEN1HSD17B10MAPTKDM4E
SCHEMBL12404386 0.79 KMT2A (0.48) KMT2AMEN1HSD17B10MAPTKDM4E
SCHEMBL26009190 0.78 MAPT (0.54) KMT2AALDH1A1MEN1MAPTKDM4E
SCHEMBL15179068 0.78 MAPT (0.54) KMT2AALDH1A1MEN1MAPTKDM4E
SCHEMBL19268519 0.78 MAPT (0.54) KMT2AALDH1A1MEN1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8426092-B2 Poly(imide-carbonate) polytetrafluoroethylene containing photoconductors XEROX CORPORATION (US) 2013-04-23 US disclosed
US-20120070769-A1 INTERMEDIATE TRANSFER MEMBER XEROX CORPORATION (US) 2012-03-22 US disclosed
US-8138300-B1 Intermediate transfer member XEROX CORPORATION (US) 2012-03-20 US disclosed
US-20120052426-A1 POLY(IMIDE-CARBONATE) POLYTETRAFLUOROETHYLENE CONTAINING PHOTOCONDUCTORS XEROX CORPORATION (US) 2012-03-01 US disclosed