SCHEMBL760381

SCHEMBL760381

COc1ccc(C2(c3ccc(OC(=O)Oc4cccc(N5C(=O)c6ccc(C(=O)c7ccc8c(c7)C(=O)N(c7cccc(OC(C)=O)c7)C8=O)cc6C5=O)c4)cc3)CCCCC2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.56
ALDH1A1 P00352 3/20 0.46
KMT2A Q03164 5/20 0.45
MEN1 O00255 4/20 0.45
LMNA P02545 1/20 0.45
NPC1 O15118 1/20 0.42
TLR9 Q9NR96 1/20 0.42
MET P08581 1/20 0.40
CA1 P00915 1/20 0.39
CA9 Q16790 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
CYP2C9 P11712 1/20 0.39
HPGD P15428 1/20 0.39
LPAR1 Q92633 1/20 0.38
LPAR5 Q9H1C0 1/20 0.38
LPAR3 Q9UBY5 1/20 0.38
ESR1 P03372 1/20 0.38
TDP1 Q9NUW8 1/20 0.37
ACHE P22303 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL759683 0.93 KMT2A (0.52) HSD17B10ALDH1A1KMT2AMEN1NPC1
SCHEMBL18563599 0.81 MAPT (0.53) HSD17B10ALDH1A1KMT2AMEN1LMNA
SCHEMBL759682 0.79 NPSR1 (0.43) HSD17B10ALDH1A1KMT2AMEN1LMNA
SCHEMBL19194913 0.77 KMT2A (0.51) ALDH1A1KMT2AMEN1LMNANPC1
SCHEMBL14877713 0.76 HSD17B10 (0.76) HSD17B10ALDH1A1KMT2AMEN1LMNA
SCHEMBL17951023 0.76 HSD17B10 (0.63) HSD17B10ALDH1A1KMT2AMEN1MET
SCHEMBL759684 0.74 HSD17B10 (0.54) HSD17B10ALDH1A1KMT2AMEN1LMNA
SCHEMBL13986180 0.74 KMT2A (0.48) ALDH1A1KMT2AMEN1LMNANPC1
SCHEMBL12919554 0.74 KMT2A (0.48) HSD17B10KMT2AMEN1LMNANPC1
SCHEMBL12404386 0.74 KMT2A (0.48) HSD17B10KMT2AMEN1LMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8426092-B2 Poly(imide-carbonate) polytetrafluoroethylene containing photoconductors XEROX CORPORATION (US) 2013-04-23 US disclosed
US-20120070769-A1 INTERMEDIATE TRANSFER MEMBER XEROX CORPORATION (US) 2012-03-22 US disclosed
US-8138300-B1 Intermediate transfer member XEROX CORPORATION (US) 2012-03-20 US disclosed
US-20120052426-A1 POLY(IMIDE-CARBONATE) POLYTETRAFLUOROETHYLENE CONTAINING PHOTOCONDUCTORS XEROX CORPORATION (US) 2012-03-01 US disclosed