Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593305 | 0.91 | KDM4A (0.44) | KDM4AKDM5AKDM5BABCB11GPR17 | |
| SCHEMBL7594828 | 0.83 | KDM4A (0.41) | KDM4AKDM5AKDM5BABCB11KCNN4 | |
| SCHEMBL27566482 | 0.74 | GPR35 (0.39) | KDM4AKDM5AKDM5BGPR17 | |
| Ethyne SCHEMBL7605585 | 0.71 | GPR17 (0.45) | KDM4AKDM5AKDM5BGPR17GRIN1 | |
| SCHEMBL7087364 | 0.67 | ABCB11 (0.52) | ABCB11KCNN4P2RX7 | |
| SCHEMBL10656615 | 0.67 | IDO1 (0.65) | KDM4AKDM5AKDM5BABCB11IDO1 | |
| SCHEMBL19331217 | 0.66 | MEN1 (0.42) | GPR17 | |
| SCHEMBL1590516 | 0.65 | RXRA (0.55) | KDM4AKDM5AKDM5BABCB11IDO1 | |
| SCHEMBL30302148 | 0.65 | RXRA (0.55) | KDM4AKDM5AKDM5BABCB11IDO1 | |
| SCHEMBL20094579 | 0.65 | GPR17 (0.63) | GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252142-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001051466-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | disclosed |