Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147671 | 1.00 | TP53 (0.48) | TP53SMN1; SMN2MEN1LMNACYP2D6 | |
| SCHEMBL11216784 | 0.82 | NPC1 (0.64) | TP53SMN1; SMN2MEN1LMNACYP2D6 | |
| SCHEMBL23424751 | 0.73 | NPC1 (0.54) | TP53SMN1; SMN2MEN1LMNACYP2D6 | |
| SCHEMBL9363533 | 0.69 | NPC1 (0.49) | TP53SMN1; SMN2MEN1LMNACYP2D6 | |
| SCHEMBL7433137 | 0.69 | MMP3 (0.52) | MMESDCBPSDC2MMP2MMP3 | |
| SCHEMBL4783425 | 0.68 | NPC1 (0.58) | TP53SMN1; SMN2MEN1LMNACYP2D6 | |
| SCHEMBL10085769 | 0.68 | SMN1; SMN2 (0.67) | TP53SMN1; SMN2MEN1LMNACYP2D6 | |
| SCHEMBL10086365 | 0.67 | NPC1 (0.73) | TP53SMN1; SMN2MEN1LMNACYP2D6 | |
| SCHEMBL7415930 | 0.67 | ALOX15 (0.69) | SMN1; SMN2MEN1LMNAKMT2ATHRB | |
| SCHEMBL7415929 | 0.67 | ALOX15 (0.69) | SMN1; SMN2MEN1LMNAKMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255726-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.P.A. (IT) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001058852-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8-INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.p.A. (IT) | 2001-08-16 | — | — | WO | disclosed |