Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632446 | 0.79 | HTR1A (0.39) | GAANPSR1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL10880376 | 0.73 | OPRM1 (0.37) | GAANPSR1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL5033288 | 0.71 | GAA (0.41) | GAANPSR1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL8749499 | 0.71 | — | — | |
| SCHEMBL8990273 | 0.71 | GAA (0.42) | GAANPSR1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL7428674 | 0.69 | OPRM1 (0.44) | GAAOPRM1ALDH1A1MEN1KMT2A | |
| SCHEMBL23762899 | 0.68 | AKR1C1 (0.48) | GAANPSR1OPRM1OPRL1MEN1 | |
| SCHEMBL29222624 | 0.68 | ALDH1A1 (0.47) | GAANPSR1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL4105893 | 0.67 | AKR1C1 (0.47) | GAANPSR1OPRM1OPRL1MEN1 | |
| SCHEMBL11812697 | 0.67 | HSD17B10 (0.41) | GAANPSR1OPRM1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417380-B1 | POLYCYCLOALKYL KETONE CONTAINING FLUORESCENT CHROMOPHORE IS ALKYLATED TO POLYCYCLOALKYLIDENE ETHER IN PRESENCE OF ALKALI METAL ALKOXIDE IN POLAR APROTIC SOLVENT | APPLIED BIOSYSTEMS, LLC | 2002-07-09 | — | — | US | disclosed |
| US-6124478-A | Methods of using 1,2-dioxetanes and kits therefore | TROPIX, INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-5856522-A | Method of using synthesis of 1,2-dioxetanes and kits therefore | TROPIX, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5777133-A | Synthesis of 1, 2-dioxetanes and intermediates therefor | TROPIX, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5679802-A | 1,2-dioxetanes useful in chemiluminescent immunoassays | TROPIX, INC. (US) | 1997-10-21 | — | — | US | disclosed |
| US-5648555-A | Alkenes | APPLIED BIOSYSTEMS, LLC | 1997-07-15 | — | — | US | disclosed |
| US-5639907-A | Synthesis of 1,2-dioxetanes and intermediates therefor | TROPIX, INC. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5637747-A | Synthesis of 1,2-dioxetanes and intermediates therefor | TROPIX, INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5625077-A | 1,2-dioxetanes | TROPIX, INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0416038-B1 | NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED | TROPIX INC (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0582317-A2 | Synthesis of 1,2-dioxetanes and intermediates therefor | TROPIX, INC. (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5177241-A | SYNTHESIS OF 1,2-DIOXETANES AND INTERMEDIATES THEREFOR | APPLIED BIOSYSTEMS, LLC | 1993-01-05 | — | — | US | disclosed |
| EP-0416038-A4 | NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED | — | 1992-02-26 | — | — | EP | disclosed |
| EP-0416038-A1 | NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED. | TROPIX INC (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4956477-A | Synthesis of 1,2-dioxetanes | TROPIX, INC. (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0368946-A1 | 1,2-DIOXETANES. | QUEST SYSTEMS INC (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0368946-A4 | 1,2-DIOXETANES. | QUEST SYSTEMS INC (US) | 1990-05-14 | — | — | EP | disclosed |
| WO-1990000164-A1 | NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED | TROPIX, INC. (US) | 1990-01-11 | — | — | WO | disclosed |
| WO-1989006226-A1 | SYNTHESIS OF 1,2-DIOXETANES AND INTERMEDIATES THEREFOR | QUEST SYSTEMS, INC. (US) | 1989-07-13 | — | — | WO | disclosed |