Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 10/20 | 0.38 |
| ▸ | DRD2 | P14416 | 8/20 | 0.38 |
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594432 | 0.89 | HTR1A (0.47) | HTR3AFAAHDRD3DRD2HTR1A | |
| SCHEMBL6773329 | 0.89 | HTR3A (0.41) | HTR3AFAAHDRD3DRD2HTR1A | |
| SCHEMBL7603029 | 0.89 | HTR1A (0.49) | HTR3ADRD3DRD2HTR1AHTR2A | |
| SCHEMBL7598268 | 0.87 | HTR3A (0.39) | HTR3AFAAHDRD3DRD2HTR1A | |
| SCHEMBL7723400 | 0.84 | HTR1A (0.52) | DRD3DRD2HTR1ADRD4ADRA1D | |
| SCHEMBL7603379 | 0.82 | HTR1A (0.52) | HTR3ADRD3DRD2HTR1AHTR7 | |
| SCHEMBL7599394 | 0.82 | HTR1A (0.44) | DRD3DRD2HTR1ADRD4HTR7 | |
| SCHEMBL7606143 | 0.81 | HTR1A (0.47) | HTR3ADRD3DRD2HTR1AHTR2A | |
| SCHEMBL7598552 | 0.81 | DRD3 (0.45) | HTR3ADRD3DRD2HTR1ADRD4 | |
| SCHEMBL7600225 | 0.81 | HTR1A (0.48) | FAAHDRD3DRD2HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |