Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 9/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603029 | 0.90 | HTR1A (0.49) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL6771603 | 0.88 | HTR1A (0.45) | HTR1ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL7599495 | 0.87 | HTR1A (0.42) | HTR1AHTR7DRD3HTR2ADRD2 | |
| SCHEMBL7597136 | 0.86 | NPC1 (0.40) | HTR1ANPC1RAB9AHTR7DRD3 | |
| SCHEMBL7594432 | 0.86 | HTR1A (0.47) | HTR1AHTR7DRD3HTR2ADRD2 | |
| SCHEMBL7596191 | 0.84 | ALDH1A1 (0.49) | HTR1AMEN1KMT2AHTR7HTR2A | |
| SCHEMBL7599324 | 0.84 | SMN1; SMN2 (0.46) | NPC1RAB9AMEN1KMT2AHTR7 | |
| SCHEMBL7723400 | 0.84 | HTR1A (0.52) | HTR1AHTR7DRD3HTR2ADRD2 | |
| SCHEMBL7603379 | 0.83 | HTR1A (0.52) | HTR1AHTR7DRD3HTR2ADRD2 | |
| SCHEMBL7594980 | 0.82 | SMN1; SMN2 (0.46) | HTR1ANPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |