Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.64 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | NEK2 | P51955 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | ACLY | P53396 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540970 | 0.88 | KEAP1 (0.68) | KMT2AMEN1MAPTSLC40A1PTGES2 | |
| SCHEMBL22233891 | 0.88 | KEAP1 (0.68) | KMT2AMEN1MAPTSLC40A1PTGES2 | |
| SCHEMBL7588697 | 0.86 | PTGES2 (0.74) | KMT2AMEN1MAPTSLC40A1PTGES2 | |
| SCHEMBL7572582 | 0.86 | CLK1 (0.67) | RECQLKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL7578880 | 0.83 | KEAP1 (0.76) | RECQLKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL7598878 | 0.83 | PTGES2 (0.62) | KMT2AMEN1MAPTALDH1A1SLC40A1 | |
| SCHEMBL1428546 | 0.82 | RECQL (1.00) | RECQLKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2055427 | 0.81 | ACLY (0.58) | RECQLKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL7537943 | 0.80 | RECQL (0.76) | RECQLKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL7573136 | 0.80 | KEAP1 (0.76) | RECQLKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |