Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GNRHR | P30968 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596779 | 0.93 | GNRHR (0.43) | MEN1KMT2AGNRHR | |
| SCHEMBL7598723 | 0.91 | GNRHR (0.36) | MEN1KMT2AGNRHRALDH1A1LMNA | |
| SCHEMBL7593455 | 0.91 | GNRHR (0.36) | MEN1KMT2AGNRHRALDH1A1LMNA | |
| SCHEMBL7591160 | 0.90 | ADORA2B (0.37) | MEN1KMT2AGNRHRALDH1A1TP53 | |
| SCHEMBL7597312 | 0.90 | MEN1 (0.36) | MEN1KMT2AGNRHRALDH1A1LMNA | |
| SCHEMBL7592912 | 0.90 | GNRHR (0.37) | MEN1KMT2AGNRHRALDH1A1LMNA | |
| SCHEMBL7597198 | 0.90 | NPSR1 (0.37) | MEN1KMT2AGNRHRALDH1A1LMNA | |
| SCHEMBL7594581 | 0.89 | GNRHR (0.35) | MEN1KMT2AGNRHRALDH1A1LMNA | |
| SCHEMBL7592330 | 0.86 | MEN1 (0.40) | MEN1KMT2AGNRHRALDH1A1LMNA | |
| SCHEMBL7598726 | 0.85 | L3MBTL1 (0.37) | MEN1KMT2AGNRHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |