Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | CASP3 | P42574 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.70 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.70 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.62 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | PHGDH | O43175 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462358 | 0.93 | HCAR3 (0.68) | HCAR3ALDH1A1NPC1MAPK1RAB9A | |
| SCHEMBL15383452 | 0.86 | HCAR3 (0.60) | HCAR3ALDH1A1NPC1MAPK1RAB9A | |
| SCHEMBL27847056 | 0.84 | PHGDH (0.74) | HCAR3ALDH1A1NPC1MAPK1RAB9A | |
| SCHEMBL2643864 | 0.84 | KMT2A (0.68) | HCAR3ALDH1A1HTTMAPTABCB1 | |
| SCHEMBL29793669 | 0.84 | KMT2A (0.68) | HCAR3ALDH1A1HTTMAPTABCB1 | |
| SCHEMBL10752705 | 0.83 | HCAR3 (0.74) | HCAR3ALDH1A1NPC1MAPK1RAB9A | |
| SCHEMBL27657641 | 0.83 | HCAR3 (0.74) | HCAR3ALDH1A1NPC1MAPK1RAB9A | |
| SCHEMBL14402986 | 0.82 | HCAR3 (0.72) | HCAR3ALDH1A1NPC1MAPK1RAB9A | |
| SCHEMBL11341363 | 0.82 | HCAR3 (0.79) | HCAR3ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL30739620 | 0.82 | HCAR3 (0.72) | HCAR3ALDH1A1NPC1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020049210-A1 | Heteroaryl amines as novel acetylcholinesterase inhibitors | CHEN YUHPYNG L (US) | 2002-04-25 | — | — | US | disclosed |
| US-6303633-B1 | FOR THERAPY AND PROPHYLAXIS OF ALZHEIMER'S DISEASE | PFIZER INC | 2001-10-16 | — | — | US | disclosed |
| US-6124321-A | Heteroaryl amines as novel acetyl cholinesterase inhibitors | PFIZER INC (US) | 2000-09-26 | — | — | US | disclosed |
| US-5965574-A | Heteroaryl amines as novel acetylcholinesterase inhibitors | CHEN YUHPYNG LIANG (US) | 1999-10-12 | — | — | US | disclosed |
| CN-1035615-C | heteroaryl amines as acetylcholinesterase inhitibors | PFIZER (US) | 1997-08-13 | — | — | CN | disclosed |
| US-5574046-A | Heteroaryl amines as novel acetylcholinesterase inhibitors | PFIZER INC. (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0606248-A1 | HETEROARYL AMINES AS NOVEL ACETYL CHOLINESTERASE INHIBITORS | Eisai Co., Ltd. (JP) | 1994-07-20 | — | — | EP | disclosed |
| CN-1071166-A | Aromatic heterocycle amine as new acetylcholinesterase depressant | PFIZER (US) | 1993-04-21 | — | — | CN | disclosed |
| WO-1993007140-A1 | HETEROARYL AMINES AS NOVEL ACETYL CHOLINESTERASE INHIBITORS | PFIZER INC. (US) | 1993-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049210-A1 | Heteroaryl amines as novel acetylcholinesterase inhibitors | ACHE, BCHE, CHAT | HCAR3 1023/4885ALDH1A1 1418/4885NPC1 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.