Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.37 |
| ▸ | DRD2 | P14416 | 8/20 | 0.37 |
| ▸ | DRD3 | P35462 | 6/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595172 | 0.97 | HTR1A (0.39) | HTR1ADRD2DRD3HTR3AHRH4 | |
| SCHEMBL7599590 | 0.92 | HTR1A (0.39) | HTR1ADRD2DRD3HTR3AHRH4 | |
| SCHEMBL7600196 | 0.92 | DRD3 (0.44) | HTR1ADRD2DRD3HTR3ASLC6A4 | |
| SCHEMBL7599794 | 0.89 | DRD2 (0.43) | HTR1ADRD2DRD3HTR3ADRD4 | |
| SCHEMBL7600219 | 0.89 | HTR1A (0.41) | HTR1ADRD2DRD3HTR3AHRH4 | |
| SCHEMBL6771131 | 0.89 | DRD3 (0.39) | HTR1ADRD2DRD3HTR3AHRH4 | |
| SCHEMBL7595828 | 0.89 | DRD3 (0.38) | HTR1ADRD2DRD3HTR3ADRD4 | |
| SCHEMBL7598996 | 0.89 | HRH3 (0.39) | HTR1ADRD2DRD3DRD4HTR2A | |
| SCHEMBL7598985 | 0.88 | HTR1A (0.41) | HTR1ADRD2DRD3SLC6A4HTR2A | |
| SCHEMBL6770160 | 0.86 | DRD3 (0.41) | HTR1ADRD2DRD3HTR3AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |