Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.41 |
| ▸ | DRD3 | P35462 | 9/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599613 | 0.92 | HTR1A (0.43) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7599794 | 0.91 | DRD2 (0.43) | HTR1ADRD3DRD2 | |
| SCHEMBL7595828 | 0.90 | DRD3 (0.38) | HTR1ADRD3DRD2HTR2A | |
| SCHEMBL7598996 | 0.90 | HRH3 (0.39) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7595172 | 0.90 | HTR1A (0.39) | HTR1ADRD3DRD2SLC6A4HRH3 | |
| SCHEMBL6771083 | 0.89 | HTR1A (0.42) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7597901 | 0.88 | HTR1A (0.37) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7600196 | 0.87 | DRD3 (0.44) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7723361 | 0.86 | DRD3 (0.53) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7602917 | 0.85 | DRD3 (0.40) | HTR1ADRD3DRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |