Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 6/20 | 0.39 |
| ▸ | NOS3 | P29474 | 4/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9845064 | 1.00 | OTC (0.47) | OTCDDAH1GSRNOS2NOS3 | |
| SCHEMBL1342779 | 0.91 | ACE (0.38) | OTCGSRNOS2NOS3NOS1 | |
| SCHEMBL9845059 | 0.84 | SMN1; SMN2 (0.39) | METAP1BLM | |
| SCHEMBL1345188 | 0.84 | SMN1; SMN2 (0.43) | CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL448333 | 0.79 | OTC (0.53) | OTCDDAH1GSRNOS2NOS3 | |
| SCHEMBL18532015 | 0.79 | OTC (0.53) | OTCDDAH1GSRNOS2NOS3 | |
| SCHEMBL9845015 | 0.78 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| SCHEMBL9845012 | 0.78 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| SCHEMBL13059111 | 0.78 | OTC (0.51) | OTCDDAH1GSRNOS2NOS3 | |
| Tilarginine SCHEMBL12028766 | 0.78 | OTC (0.51) | OTCDDAH1GSRNOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156129-A1 | Method of treating pruritus and a pharmaceutical composition for the method | IKEDA MOHANDO CO., LTD. (JP) | 2002-10-24 | — | — | US | claimed |
| US-20020156129-A1 | Method of treating pruritus and a pharmaceutical composition for the method | IKEDA MOHANDO CO., LTD. (JP) | 2002-10-24 | — | — | US | disclosed |
| EP-0446699-A1 | Inhibitors of nitric oxide biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-09-18 | — | — | EP | disclosed |