SCHEMBL448333

SCHEMBL448333

N=C(NO)NCCC[C@H](N)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OTC P00480 1/20 0.53
DDAH1 O94760 3/20 0.46
GSR P00390 2/20 0.46
NOS3 P29474 3/20 0.44
NOS1 P29475 3/20 0.44
NOS2 P35228 3/20 0.44
ARG2 P78540 4/20 0.42
ARG1 P05089 3/20 0.42
CYP1A2 P05177 2/20 0.41
GLA P06280 1/20 0.41
TSHR P16473 1/20 0.41
NFKB1 P19838 1/20 0.41
APEX1 P27695 1/20 0.41
CYP2C19 P33261 1/20 0.41
GRM8 O00222 1/20 0.39
GRM6 O15303 1/20 0.39
GRIN2D O15399 1/20 0.39
GRIN3B O60391 1/20 0.39
GRIK1 P39086 1/20 0.39
GRM5 P41594 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nor-Noha SCHEMBL4097591 0.89 GSR (0.42) OTCGSRNOS3NOS1NOS2
Nor-Noha SCHEMBL14754841 0.89 GSR (0.42) OTCGSRNOS3NOS1NOS2
SCHEMBL18532015 0.86 OTC (0.53) OTCDDAH1GSRNOS3NOS1
Tilarginine SCHEMBL6370536 0.84 OTC (0.51) OTCDDAH1GSRNOS3NOS1
SCHEMBL13059111 0.84 OTC (0.51) OTCDDAH1GSRNOS3NOS1
SCHEMBL21089964 0.84 OTC (0.51) OTCDDAH1GSRNOS3NOS1
Tilarginine SCHEMBL12028766 0.84 OTC (0.51) OTCDDAH1GSRNOS3NOS1
Tilarginine SCHEMBL315843 0.84 OTC (0.51) OTCDDAH1GSRNOS3NOS1
SCHEMBL25216092 0.83 OTC (0.50) OTCDDAH1GSRNOS3NOS1
SCHEMBL8730134 0.83 NOD1 (0.52) OTCDDAH1GSRNOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1527196-A4 TREATMENT FOR ASTHMA OR ALLERGIES CHILDRENS HOSP MEDICAL CENTER (US) 2007-03-14 EP claimed
EP-1527196-A2 TREATMENT FOR ASTHMA OR ALLERGIES CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2005-05-04 EP claimed
WO-2003073990-A2 TREATMENT FOR ASTHMA OR ALLERGIES CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2003-09-12 WO claimed
WO-1994016740-A1 THE USE OF NITRIC OXIDE-DELIVERING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF ALCOHOLIC LIVER INJURY BRIGHAM AND WOMEN'S HOSPITAL (US) 1994-08-04 WO claimed
EP-3523274-B1 FORMULATIONS FOR ADMINISTRATION OF EFLORNITHINE ORBUS THERAPEUTICS INC (US) 2025-11-05 EP disclosed
US-20250255850-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2025-08-14 US disclosed
CN-119780447-A Biomarker for early pregnancy related state of dairy cows and application thereof 宁夏大学 2025-04-08 CN disclosed
US-12226425-B2 Inhibitors of ARG1 and/or ARG2 ARCUS BIOSCIENCES, INC. (US) 2025-02-18 US disclosed
US-20240316006-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-09-26 US disclosed
US-12054500-B2 Arginase inhibitors ARCUS BIOSCIENCES, INC. (US) 2024-08-06 US disclosed
EP-4337197-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2024-03-20 EP disclosed
US-11931364-B2 Modulation of the nitric oxide synthase pathway for oral health MEHARRY MEDICAL COLLEGE (US) 2024-03-19 US disclosed
US-20020006913-A1 ANTIMUTAGENIC COMPOSITIONS FOR TREATMENT AND PREVENTION OF PHOTODAMAGE TO SKIN PRO-NEURON, INC. 2002-01-17 US disclosed
US-20010044421-A1 Administering to skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering deoxyribonucleosides to skin cells PRO-NEURON, INC. 2001-11-22 US disclosed
US-20010044419-A1 Antimutagenic compositions for treatment and prevention of photodamage to skin PRO-NEURON, INC. 2001-11-22 US disclosed
WO-2001085981-A2 METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) 2001-11-15 WO disclosed
US-6255290-B1 REDUCING SENSITIVITY TO SKIN CANCER; TOPICAL ADMINISTERING OF NUCLEOTIDE PRO-NEURON, INC. 2001-07-03 US disclosed
US-6028054-A ORALLY ADMINISTERING PHARMACEUTICAL COMPOUND TO MAMMAL IN NEED OF TREATMENT WITH COMPOUND CONCURRENTLY WITH BIOENHANCER COMPRISING INHIBITOR OF CYTOCHROME P450 3A ENZYME OR INHIBITOR OF P-GLYCOPROTEIN-MEDIATED MEMBRANE TRANSPORT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-02-22 US disclosed
WO-2000003721-A1 IMMUNOSUPPORTIVE DRUG SPARING DIET BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2000-01-27 WO disclosed
WO-1994016740-A1 THE USE OF NITRIC OXIDE-DELIVERING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF ALCOHOLIC LIVER INJURY BRIGHAM AND WOMEN'S HOSPITAL (US) 1994-08-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12054500-B2 Arginase inhibitors ARG1, ARG2, ARGLU1 OTC 48/4885DDAH1 233/4885GSR 2236/4885
US-20240316006-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS NLN, ACHE, SMN1; SMN2 OTC 10/4885DDAH1 1437/4885GSR 52/4885
US-20250255850-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS NLN, ACHE, PYGB OTC 9/4885DDAH1 1184/4885GSR 63/4885
US-11931364-B2 Modulation of the nitric oxide synthase pathway for oral health TAS2R4, GMPS, BPHL OTC 1312/4885DDAH1 683/4885GSR 50/4885
US-12226425-B2 Inhibitors of ARG1 and/or ARG2 ARG1, ARG2, ARGLU1 OTC 719/4885DDAH1 706/4885GSR 4088/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.